CompositionCetirizine (5mg),Dextromethorphan (10mg),Pseudoephedrine (30mg) SALT INFORMATIONCetirizine (5mg) TYPICAL USAGE Allergic rhinitis, ocular symptoms like redness, lacrimation and itching. Urticaria, dermographism, atopic eczema and contact dermatitis, acute allergic reactions due to drugs, foods, insect bites. SIDE EFFECTS Somnolence, insomnia, malaise, headache, dizziness, GI discomfort, dry mouth, abdominal pain, diarrhoea, nausea, vomiting; occasional hypersensitivity, epistaxis, pharyngitis, bronchospasm. DRUG INTERACTION Risk of increased INR and epistaxis when taken together with warfarin. CNS depressants and anticholinergics may potentiate CNS depression of cetirizine. MECHANISM OF ACTION Cetirizine is a potent and highly selective antagonist of the peripheral histamine H1-receptor on effector cells in the GI tract, blood vessels and respiratory tract. Dextromethorphan (10mg) TYPICAL USAGE Dry cough. SIDE EFFECTS Dependency, dizziness, drowsiness, vomiting, restlessness, mental confusion, excitation. DRUG INTERACTION Dextromethorphan is known to interact with other drugs like abiraterone acetate, amiodarone (HCl), fluoxetine (HCl), haloperidol, mitomycin C, moclobemide, paroxetine, phenelzine, propafenone (HCl), quinidine, sibutramine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. Pseudoephedrine (30mg) TYPICAL USAGE Bronchospasm, Nasal congestion, Rhinitis, Upper respiratory tract infections. SIDE EFFECTS Drowsiness, Anorexia, Anxiety, Restlessness, Insomnia, Sleep disturbancesX, Dry mouth, Tremor. DRUG INTERACTION Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs MECHANISM OF ACTION Pseudoephedrine is both an ?-and ?-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of ?-adrenergic receptors of the respiratory mucosa. It also directly stimulates ?-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.