CompositionOndansetron (4 mg)
SALT INFORMATIONOndansetron (4 mg) TYPICAL USAGE Advanced ovarian cancer, Lung cancer, Moderately emetognic chemotherapy or radiotherapy, Nausea and vomiting (chemotherapy induced), Post operative vomiting, Post-operative nausea, Post-operative nausea and vomiting, Prevention of post-operative nausea and vomiting, Severely emetognic chemotherapy. SIDE EFFECTS Dizziness, Headache, Fever, Dyspnea, Constipation, Abdominal pain, Chills, Hypotension, Flushing. DRUG INTERACTION Rifampicin and other CYP3A4 inducers reduce levels/effects of ondansetron. MECHANISM OF ACTION Ondansetron antagonises 5-HT3 receptor, blocking serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone.