CompositionAlprazolam (0.25 mg)
SALT INFORMATIONAlprazolam (0.25 mg) TYPICAL USAGE Mild depression. Panic disorders. Anxiety associated with depression. SIDE EFFECTS Psychological and physical dependence with withdrawal syndrome, fatigue, drowsiness, sedation, ataxia, vertigo, confusion, depression, GI disturbances, changes in salivation, amnesia, jaundice, paradoxical excitation, elevated liver enzyme values; muscle weakness, visual disturbances, headache, slurring of speech and dysarthria, mental changes, incontinence, constipation, hypotension, tachycardia, changes in libido, pain and thrombophlebitis at inj site (IV). DRUG INTERACTION Increased clearance of diazepam when used with phenytoin, carbamazepine and phenobarbital. Reversible deterioration of parkinsonism may occur when given together with levodopa. Combination with lithium may produce hypothermia. May need to reduce dose of narcotics when used concurrently. MECHANISM OF ACTION Alprazolam is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant and amnestic properties. It increases neuronal membrane permeability to chloride ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron within the CNS and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.
CompositionOfloxacin (50 mg)
SALT INFORMATIONOfloxacin (50 mg) TYPICAL USAGE Genito urinary, respiratory, gastro intestinal. skin and soft tissue infections. Peritonitis, Gonorrhoea. Typhoid fever, Multi drug resistant tuberculosis. Acute and sub-acute eye and ear infections. SIDE EFFECTS Sinus tachycardia, hallucinations, stevens johnson syndrome, seizures, tendon rupture, dizziness, headache, nausea, vomiting, diarrhea, insomnia, abdominal pain, pruritus, photosensitivity. DRUG INTERACTION Ofloxacin is known to interact with other drugs like aluminium hydroxide and oxide, didanosine, iron Salts, pentostatin, probenecid, procainamide (HCl), sucralfate, theophylline. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.
CompositionEtamsylat (500 mg)
SALT INFORMATIONEtamsylat (500 mg) TYPICAL USAGE Haemorrhage, short-term treatment of blood loss in menorrhagia. SIDE EFFECTS Hypotension, headache, nausea, skin rashes. DRUG INTERACTION Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval. MECHANISM OF ACTION Ethamsylate stops haemorrhage from small blood vessels by stabilising the capillary wall and correcting abnormal platelet adhesion.
CompositionMethylcobalamin (500 mcg)
SALT INFORMATIONMethylcobalamin (500 mcg) TYPICAL USAGE peripheral neuropathy, megaloblastic anaemia SIDE EFFECTS Anorexia, nausea, vomiting and diarrhoea. DRUG INTERACTION Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. MECHANISM OF ACTION Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
CompositionProgesterone (200 mg)
SALT INFORMATIONProgesterone (200 mg) TYPICAL USAGE Recurrent miscarriage, amenorrhoea, abnormal uterine bleeding, palliative treatment of advanced, inoperable endometrial carcinoma SIDE EFFECTS GI disturbances, increased appetite, weight gain or loss, oedema, acne, allergic skin rashes, urticaria, mental depression, discomfort in breast, cough, dyspnoea. DRUG INTERACTION Hydroxyprogesterone caproate is known to interact with other drugs like carbamazepine, phenytoin, ciclosporin. MECHANISM OF ACTION Hydroxyprogesterone caproate stimulates luteal actions, changes in uterus and vagina as seen in early pregnancy. It also has prolonged uterotrophic effect. Contractile response of the myometrium to oxytocin is inhibited.
CompositionSildenafil (50 mg)
SALT INFORMATIONSildenafil (50 mg) TYPICAL USAGE For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH). SIDE EFFECTS Headache, flushing, respiratory tract infection, angina pectoris, AV block, migraine, syncope. DRUG INTERACTION Inhibitors of CYP3A4 such as cimetidine and erythromycin are likely to reduce sildenafil clearance. MECHANISM OF ACTION Sildenafil inhibits phosphodiesterase type-5 (PDE5) which is responsible for cGMP degradation in the corpus cavernosum. Inhibition of PDE5 increases cGMP levels in the corpus cavernosum which results in smooth muscle relaxation and inflow of blood to the corpus cavernosum.
CompositionCefixime (200 mg)
SALT INFORMATIONCefixime (200 mg) TYPICAL USAGE Infections of respiratory, urinary and biliary tract. Salmonella infection. SIDE EFFECTS Pseudomembranous colitis, thrombocytopenia, thrombophlebitis, leucopenia, seizures, flatulence, dizziness, headache, nausea, vomiting, anorexia, diarrhea, abdominal pain, urticaria, pruritus, dyspepsia, hypersensitivity. DRUG INTERACTION Probenecid may increase the blood concentration of cefixime by decreasing removal of cefixime by the kidney. May increase prothrombin time with anticoagulants. MECHANISM OF ACTION Cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.
CompositionCiprofloxacin (750 mg)
SALT INFORMATIONCiprofloxacin (750 mg) TYPICAL USAGE Urinary tract infections. Gonorrhoea. Chancroid. Bacterial Gastroenteritis. Typhoid. Bone, soft tissue, gynaecological and wound infections. Respiratory infections. Tuberculosis. Gram-negative septicaemias. Neningitis. Prophylaxis. Conjunctivitis. SIDE EFFECTS Pseudomembranous colitis, hearing loss, seizures, stevens johnson syndrome, acute renal failure, fluminant hepatic failure, dizziness, headache, nausea, vomiting, diarrhea, tachycardia, nervousness, termors, rashes, urticaria, pruritus, photosensitivity, elevation of liver enzymes. DRUG INTERACTION Ciprofloxacin is known to interact with other drugs like caffeine, chloramphenicol, clozapine, cyclosporin A, methotrexate, multiple vitamins, naproxen, pentostatin, phenytoin (Na), probenecid, rifampicin, rutin (Vitamin P), sucralfate, theophylline, warfarin (Na). MECHANISM OF ACTION The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination.