CompositionGranisetron (1 mg)
SALT INFORMATIONGranisetron (1 mg) TYPICAL USAGE Nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy. Prophylaxis and treatment of postoperative nausea and vomiting. SIDE EFFECTS Headache, sensation of flushing, constipation, hypersensitivity reactions, chest pain, CV disturbances, dizziness, transient visual disturbances. DRUG INTERACTION Granisetron is known to interact with other drugs like dexamethasone. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Granisetron is a potent, selective antagonist of 5-HT3 receptors. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.