SALT INFORMATIONMinoxidil (5%) TYPICAL USAGE Alopecia androgenetia (male pattern baldness) alopecia areata. Severe HTN unresponsive to standard therapy. SIDE EFFECTS Oedema, ascites, tachycardia, headache, nausea, palpitation, flushing, breast tenderness, hypertrichosis. DRUG INTERACTION Minoxidil is known to interact with other drugs like Clonidine (HCl), Nadolol, Nicorandil, propranolol (HCl), tretinoin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Minoxidil is thought to promote the survival of human dermal papillary cells (DPCs) or hair cells by activating both extracellular signal-regulated kinase (ERK) and Akt and by preventing cell death by increasing the ratio of BCl-2/Bax. Minoxidil may stimulate the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs. Minoxidil, when used as a vasodilator, acts by opening adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells.