CompositionFluconazole (100 mg)
SALT INFORMATIONFluconazole (100 mg) TYPICAL USAGE Adjunct in heart failure, adjunct in stable moderate to severe heart failure, adjunctive therapy without valproate, all forms of epilepsy, candidiasis, fungal infection, hormone-mediated secretory diarrhea, hormone-mediated secretory diarrhea (but can be of benefit in refactory cases), hormone-mediated secretory diarrhea (can be benefit in refactory cases), nausea and vomiting. SIDE EFFECTS Elevated alkaline phosphatase concentration, elevated hepatic enzymes, dizziness, headache, nausea, vomiting, diarrhea, abdominal pain, rashes, hypokalemia, pallor, anaphylaxis, leucopenia. DRUG INTERACTION Fluconazole is known to interact with other drugs like alfentanil (HCl), aliskiren, alprazolam, amitriptyline (HCl), artesunate, astemizole, bosentan, celecoxib, chlorpropamide, cisapride, cyclosporin A, fosphenytoin, hydrochlorothiazide, loratadine, losartan (K), nortriptyline (HCl), phenytoin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Fluconazole interacts with 14-? demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents.