SALT INFORMATIONTobramycin (0.003) TYPICAL USAGE Bacterial infections, biliary tract infections, chronic pulmonary pseudomonas aeruginosa infection in cystic fibrosis patients, cystic fibrosis, endocarditis, eye infections, gram +ve (some) and gram -ve (many) infections, heart failure, iron deficiency anaemia, NSAID-associated ulceration, oliguria due to renal failure, pneumonia in hospital patients, prophylaxis of stress ulceration, respiratory tract infections. SIDE EFFECTS Ototoxicity, elevation in serum creatinine, neuromuscular blockage, skin reactions, maculopapular rash, urticaria, local pain, phlebitis. DRUG INTERACTION Tobramycin is known to interact with other drugs like atracurium (Besylate), calcium gluconate, carbenicillin (Na), cefaclor (Monohydrate), cefotaxime, cephaloridine, cisplatin, ethacrynic acid, frusemide or furosemide, gentamicin, piperacillin (Na), polymyxin B (Sulphate), tubocurarine (Cl), vancomycin (HCl), vecuronium (Br). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA.