CompositionMethylprednisolone (16 mg)
SALT INFORMATIONMethylprednisolone (16 mg) TYPICAL USAGE Allergy, angioneurotic edema, asthma, autoimmune disease, collagen disease, crohn's disease, dermatological diseases, eczema, endocrine disorder, GI diseases, graft rejection, leukaemia, lymphoma, multiple sclerosis, nephrotic syndrome, ocular inflammation, opthalmic disease. SIDE EFFECTS Hypercalciuria, congestive heart failure, telangiectasia, glaucoma, cataract, insomnia, fluid retension, CHO intolerance, peptic ulceration, hypertension, osteoporosis, growth retardation, aseptic bone necrosis, viral infections, hypokalemic alkalosis, hemorrhages, erythema, itching, burning, acneform, folliculitis, striae, hypertrichosis/gingival hypertrophy, fragility of skin, menstrual irregularity, facial erythema, perioral dermatitis, allergic skin reactions, cushing syndrome, hypopigmentation. DRUG INTERACTION Methylprednisolone is known to interact with other drugs like amphotericin B, aspirin, carbamazepine, cyclophosphamide, cyclosporin A, erythromycin, estrogens conjugated, glibenclamide, lofexidine, metyrosine, phenobarbitone, phenytoin (Na), pyridostigmine (Br), rifampicin, rotavirus vaccine, tacrolimus. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.