CompositionMetolazone (5 mg)
SALT INFORMATIONMetolazone (5 mg) TYPICAL USAGE Congestive heart failure, edema, hepatic disease, hypertension, oedema, renal failure. SIDE EFFECTS Hypokalemia, hyperglycemia, headache, constipation, rashes, vertigo, muscle cramps, nocturia. DRUG INTERACTION Metolazone is known to interact with other drugs like bumetanide, captopril, cyclosporin A, frusemide or furosemide. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Metolazone acts primarily to inhibit sodium reabsorption at the cortical diluting site and to a lesser extent in the proximal convoluted tubule. Sodium and chloride ions are excreted in approximately equivalent amounts. The increased delivery of sodium to the distal tubular exchange site results in increased potassium excretion. Metolazone does not inhibit carbonic anhydrase.