Source of Pure Glutamine
Over 60% of skeletal muscles constitute glutamine which is a primary transporter of nitrogen in your body. Intense training depletes levels of glutamine, slowing down protein synthesis. L-glutamine in this supplement supports better muscle recovery, reduces muscle soreness and rebuilds your muscle tissues.
Unflavoured, thus Goes with Everything
The supplement has no flavour of its own, so it can be mixed directly with food and beverages without altering their taste. It mixes instantly with milk, water, juice etc.
Useful for Those Wanting to ‘Cut Down’
Remember those times when you want to lose fat only, without losing the muscle? That’s where glutamine comes in. The immune system also requires glutamine as the natural levels deplete after a rigorous workout. External intake of glutamine ensures your immune system stays in a robust shape.
HOW, HOW MUCH AND WHEN
5-15 g per day of Glutamine supplement would be sufficient to raise plasma Glutamine concentrations in our body. Take Glutamine with foods or liquids that are at room temperature. It should not be added taken with hot beverages, because heat destroys Glutamine.
For children up to 10 years and younger: Do not give Glutamine to a child unless the doctor recommends it as part of a complete amino acid supplement.
For adults who are 18 years and older: Doses of 500g, 1 - 3 times daily, are generally considered safe. Doses as high as 5,000 - 15,000 mg daily (in divided doses), or sometimes higher may be prescribed by a health care provider for certain conditions. Glutamine supplements are required when the body levels of Glutamine are low. And the body’s Glutamine levels are at their lowest after intense physical activity. Glutamine should be taken as soon as possible after finishing a workout. Most bodybuilders prefer to add Glutamine supplements to their post-workout shake. Glutamine is mostly tasteless.
WHAT IS GLUTAMINE?
Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations including intensive athletic training or certain gastrointestinal disorders. Its side-chain is an amide formed by replacing the side-chain Hydroxyl Of Glutamic Acid with an amine functional group, making it the amide of Glutamic Acid. In human blood, Glutamine is the most abundant free amino acid with a concentration of about 500–900 µmol/l. Most Glutamine is stored in muscles followed by the lungs, where much of the Glutamine is made. Glutamine is important for removing excess Ammonia (a common waste product in the body). It also helps the immune system function properly and is needed for the normal functioning of the brain as well as digestion. Glutamine has gained importance through various studies which revealed its unique contribution to protein synthesis (muscle growth), anti-catabolic breakdown functions (prevents muscle tissue from breaking down) and growth hormone elevating effects. Due to these effects, Glutamine plays an important part in the body by aiding recovery of muscle cells. Under normal circumstances, the human body is more than capable of producing enough Glutamine that is necessary. But in some cases, more Glutamine is required than the human body is able to produce, this is called Glutamine depletion. Glutamine depletion can be caused by illness like the common cold, extensive burns, surgery etc. The other main cause of Glutamine depletion is intense physical exercise.
WHAT DOES GLUTAMINE DO?
Producing and consuming organs
Glutamine is synthesized by the enzyme Glutaminesynthetase that is made from Glutamate and Ammonia. The most relevant Glutamine producing tissue is the muscle mass that accounts to 90% of all the Glutamine that is synthesized in the body. Glutamine is also released in small amounts by the lungs and the brain. Although the liver is capable of relevant Glutamine synthesis, its role in Glutamine metabolism is more regulatory than producing, since the liver takes up large amounts of Glutamine that is derived from the gut.
The most eager consumers of Glutamine are cells of intestines, the kidneys cells for acid-base balance, activated immune cells and many cancer cells. It is also regarded as an anti-cancer amino acid.
HOW IT FUNCTIONS?
Glutamine is best known for its ability to serve as a source of fuel for the cells that line the gastrointestinal tract. More specifically, Glutamine is the preferred fuel source for cells lining the walls of the small intestine. By nourishing these cells, Glutamine helps maintain the health and integrity of the gastrointestinal tract. A healthy gastrointestinal tract is vital to preserve the overall well-being of the body, as the lining of the gastrointestinal tract serves as a first line of defense against disease-causing micro organisms and also minimizes the absorption of potentially allergenic molecules. Glutamine also serves as a source of fuel for muscle and immune cells. In addition, Glutamine plays a vital role in maintaining the body's proper acid-base balance. Glutamine is synthesized from glutamate and ammonia. Ammonia is a toxic waste compound with a high pH value, meaning that it is basic in nature (as opposed to acidic). When ammonia levels are elevated, the body clears ammonia from the blood by synthesizing Glutamine. If the blood is too acidic (pH too low), then the body can break down Glutamine into glutamate and ammonia to increase the pH of the blood. Glutamine also serves as a precursor to the antioxidant glutathione participates in glycogen synthesis (the storage form of carbohydrate) and provides nitrogen compounds for the manufacture of nucleotides which are used to make DNA and RNA.
When the body is stressed (from injuries, infections, burns, trauma, or surgical procedures), it releases the hormone Cortisol into the blood stream. High levels of Cortisol can lower the levels of Glutamine inside the body. Several studies show that adding Glutamine to enteral nutrition (tube feeding) helps reduce the chance of death in trauma and critically ill people. Clinical studies have found that Glutamine supplements strengthen the immune system and reduce infections (particularly infections associated with surgery). Glutamine supplements may also help in the recovery of severe burns.
Glutamine helps in protecting the lining of the gastrointestinal tract known as the Mucosa. For the same reason, some have suggested that people who have inflammatory bowel disease (Ulcerative Colitis and Crohn's disease) may not have enough Glutamine in their body. However, 2 clinical trials found that taking Glutamine supplements did not improve symptoms of Crohn's disease.
Athletes who train for endurance events (like marathons) may have reduced amounts of Glutamine in their bodies after strenuous exercise. For the same reason it is common for them to catch a cold after any athletic event. For a select group of athletes, one study showed that taking Glutamine supplements resulted in fewer infections. However, the same is not true, for exercisers who work out with moderate intensity.
WHO SHOULD TAKE GLUTAMINE?
Even though L-Glutamine is a very important part of a bodybuilders' supplementation, L-Glutamine is not just for bodybuilders. Glutamine is essential for maintaining a sound intestinal function and aiding in the immune response as well. After Glutamine is synthesized in the skeletal muscle, it is released into the bloodstream and transported to the kidney, liver, small intestine and cells of the immune system where it plays another vital role. Glutamine is used by white blood cells and contributes to normal immune-system function. Individuals with muscle wasting and immune system related illnesses, who may be incapable of manufacturing their own supply of Glutamine, may benefit from Glutamine supplements taken along with other amino acids. Becoming ill or losing lean muscle mass are potential signs of Glutamine deficiency. Not only is Glutamine important for bodybuilders to help prevent catabolism, but also it is important for regular use by the average person.
What is the difference between Glutamine and L-Glutamine?
The ’L’ stands for Levo. Many complex chemicals exist in 2 forms.They are identical chemically, but are the mirror images of each other. One is Levo or left, the other is Dexter or right. When mixed together, the chemical containing L+D and is called a Race mate. When separated, the two forms are called Isomers. Sometimes only one is chemically active in the body and the other may be less active or completely inert and unusable.
Will Glutamine help me with my health maintenance and exercise program?
Glutamine plays a major role in the synthesis of DNA and serves as a primary transporter of nitrogen to the muscle tissues. It serves to replenish nitrogen loss due to excessive muscle training and speeds up recovery. It is so vital to the building and maintenance of muscle tissue, that 60% of the human intracellular amino acid pool is Glutamine. The very fact that muscle is the most important tissue for Glutamine synthesis and storage is the evidence of Glutamine’s vital role in maintaining positive nitrogen balance and building these important support structures inside the body.
Glutamine is utilized at a high rate by the cells of the immune system. It is also necessary for the production of hormone-like proteins secreted by immune cells that regulate the intensity and duration of an immune response to foreign organisms.
What heppens if Glutamine deficiency occurs?
Glutamine deficiency is common in today's busy lifestyle and in the primary tests conducted by medical practitioners who utilize blood tests to ascertain the amino acid levels present in patients with symptoms of chronic illness, dysfunction in cognitive functioning and mood swings, making it an increasingly popular substance not just in the athletic world but in medical practice. During periods of stress, trauma or simply intensive sports training, Glutamine depletion occurs which manifests itself in the form of decreased strength, stamina and recovery - taking anywhere up to six days to return to normal levels. Research has shown that during intense resistance training, Glutamine levels can be reduced by up to 50%.
Will it increase my growth hormone levels?
Glutamine supplementation after exercise increases growth hormone levels. Glutamine increases the levels of the amino acids Arginine and Glutamate, which are capable of boosting growth hormones. Growth hormones are strong protein anabolic agents that improve nitrogen sparing and protein retention by increasing protein synthesis. Growth hormone stimulates the breakdown of fat and spares carbohydrate stores.
Who should take Glutamine?
Glutamine can be very helpful if:
Performing any type of serious workout;
While going through any type of stressful event;
Fighting off the cold or flu.
Bodybuilders can particularly gain from the intake of Glutamine. Since bodybuilders use a lot of their Glutamine while working out, they are more susceptible to health related problems, as the immune system relies heavily on this amino acid.
Catabolism or muscle break down can occur if the body robs muscles of Glutamine for use elsewhere, such as nitrogen transport or maintaining the immune system. Glutamine supplementation is certainly important in muscle development.
Who should not take Glutamine?
People with kidney problems
People with cirrhosis of the liver
Women who are breast feeding
While on any medication or suffering from any medical condition, consulting the doctor before taking any dietary supplement is advised.