CompositionDexamethasone Sodium Phosphate (),Ofloxacin (0.3 % w/v)
SALT INFORMATIONDexamethasone Sodium Phosphate () TYPICAL USAGE Anorexia in palliative care, congenital adrenal hyperplasia, dyspnoea, dyspnoea in palliative care, headache due to raised intracranial pressure in palliative care, nausea and vomiting (chemotherapy induced), pain due to nerve compression in palliative care, raised intracranial pressure, respiratory distress syndrome, shock, suppression of inflammatory and allergic disorders. SIDE EFFECTS Glaucoma, peptic ulceration, myopathy, osteoporosis, growth retardation, aseptic bone necrosis, ocular hypertension, subcapsular cataract, pancreatic disturbance, cushing like features, oedema, retinal detachment, nausea, vomiting, insomnia, nervousness, nocturia, increased appetite, obesity, facial rounding, fragility of skin, euphoria, glucose intolerance. DRUG INTERACTION Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval. MECHANISM OF ACTION Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to DNA elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Ofloxacin (0.3 % w/v) TYPICAL USAGE Genito urinary, respiratory, gastro intestinal. skin and soft tissue infections. Peritonitis, Gonorrhoea. Typhoid fever, Multi drug resistant tuberculosis. Acute and sub-acute eye and ear infections. SIDE EFFECTS Sinus tachycardia, hallucinations, stevens johnson syndrome, seizures, tendon rupture, dizziness, headache, nausea, vomiting, diarrhea, insomnia, abdominal pain, pruritus, photosensitivity. DRUG INTERACTION Ofloxacin is known to interact with other drugs like aluminium hydroxide and oxide, didanosine, iron Salts, pentostatin, probenecid, procainamide (HCl), sucralfate, theophylline. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.