Tablets and Capsules,Prescription Medicines

Prax A 75mg Cap

Availablity: In stock

1 Strip of 10 tablets. This Product is manufactured by Torrent pharmaceuticals ltd

₹ 180.00

Composition: Prasugrel 5mg + Asprin 75mg

Prasugrel:

Typical Usage:

  • Prasugrel is used either alone or along with aspirin by patients with recent heart attack, unstable angina, who undergo a certain angioplasty.

Mechanism of action:

  • Prasugrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets. These agents reduce the aggregation of platelets by irreversibly binding to P2Y12 receptors. 

Contraindications:

  • Prasugrel should not be given to patients with active pathological bleeding, such as peptic ulcer or a history of transient ischemic attack or stroke, because of higher risk of stroke.

Adverse Effects:

  • Abnormal Liver, abdominal bleeding, decreased blood platelets, decreased white blood cells, decreased blood platelets, decreased white blood, Giant Hives.

Drug interaction:

  • Prasugrel on coadministration with NSAIDS and warfarin may increase the risk of bleeding.

 

Asprin:

  • Aspirin, also known as acetylsalicylic acid [ASA], often used as an analgesic to relieve minor pains and to reduce fever (antipyretic), and as an anti-inflammatory medication. It is also has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds platelet molecules together to create a patch over damaged walls of blood vessels and block blood vessels.

Typical uses:

  • It is used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in people at high risk of developing blood clots.


Mechanism of action:
The effect of asprin is dose dependent as below:

  • Low doses (75 to 150 mg/day) are sufficient to irreversibly acetylate serine 530 of cyclooxygenase (COX)-1 leads to inhibition of platelet generation of thromboxane A2, resulting in an antithrombotic effect.
  • Intermediate doses (650 mg to 4 g/day) inhibit COX-1 and COX-2, blocking prostaglandin (PG) production, and have analgesic and antipyretic effects.

Adverse effects:

  • Gastrointestinal ulcers, stomach bleeding, and ringing in the ears, especially with higher doses.
  • In children and adolescents, aspirin is not recommended for flu-like symptoms or viral illnesses, because of the risk of Reye's syndrome.

 Drug Interactions:

  • Asprin may interact with alcohol, corticosteroids, analgin.
  • Asprin on concurrent administration with Phenylbutazone and oxyphenbutazonen may increase risk of GI ulceration.
  • It may potentiate the effects of of anticoagulants, methotrexate and oral hypoglycemic drugs.

Schedule: H

 

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