CompositionAlpha Lipoic Acid (100 mg.),Folic Acid (0.5 mg.),Inositol (100 mg),Mecobalamin (500 mcg.),Chromium Polynicotinate (65 mcg) SALT INFORMATIONAlpha Lipoic Acid (100 mg.) TYPICAL USAGE Antioxitent SIDE EFFECTS Thiamine deficiency, low blood sugar levels. DRUG INTERACTION Alfa lipoic acid is known to interact with other drugs like metformin, glyburide. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Lipoic acid exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of the R-enantiomer when a racemic mixture is given. The S-enantiomer has been found to reduce the expression of GLUT-4s in cells, responsible for glucose uptake, and hence reduce insulin sensitivity. Folic Acid (0.5 mg.) TYPICAL USAGE Folate-deficient. Megaloblastic anaemia. Prophylaxis of megaloblastic anemia in pregnancy. Prophylaxis of neural tube defect in pregnancy. Malabsorption syndromes. Antiepileptic therapy. SIDE EFFECTS Neuropathy, bronchospasm, itchy skin eruptions, malaise. DRUG INTERACTION Interacts with other drugs like deferoxamine, epoetin, fosphenytoin, methotrexate, sulphasalazine. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase. Inositol (100 mg) TYPICAL USAGE Diabetes SIDE EFFECTS Nausea, stomach upset, skin rash, acute toxicity. DRUG INTERACTION No data regarding the interactions of Inositol was found. MECHANISM OF ACTION It's mode of action is contradictory.Many hypothesis have been given to explain its mechanism of action.One of the hypothesis is Inositol might balance certain chemicals in the body to possibly help with conditions such as panic disorder, depression, obsessive-compulsive disorder, and "polycystic ovary syndrome." Mecobalamin (500 mcg.) TYPICAL USAGE Peripheral neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis. SIDE EFFECTS Anorexia, nausea, vomiting and diarrhoea, rash, headache, hot sensation, diaphoresis and pain or induration at IM injection site. DRUG INTERACTION Methylcobalamin is known to interact with other drugs like neomycin, aminosalicylic acid, H2-blockers and colchicine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Methylcobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes. Chromium Polynicotinate (65 mcg) TYPICAL USAGE Diabetes mellitus, Treatment of locally advanced or metastatic pancreatic cancer. SIDE EFFECTS Convulsions, Hepatic damage, Coma, Nausea & vomiting, GI ulcer, Renal damage. DRUG INTERACTION None well documented. MECHANISM OF ACTION Not Known.