CompositionMecobalamin (750mcg),Pregabalin (75mg) SALT INFORMATIONMecobalamin (750mcg) TYPICAL USAGE Peripheral neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis. SIDE EFFECTS Anorexia, nausea, vomiting and diarrhoea, rash, headache, hot sensation, diaphoresis and pain or induration at IM injection site. DRUG INTERACTION Methylcobalamin is known to interact with other drugs like neomycin, aminosalicylic acid, H2-blockers and colchicine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Methylcobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes. Pregabalin (75mg) TYPICAL USAGE Adjunctive treatment of partial seizures, Epilepsy, Fibromyalgia, Neuropathic pain. SIDE EFFECTS Flatulence, Dizziness, Vomiting, Constipation, Dry mouth, Blurred vision, Weight gain, Somnolence, Diplopia, Edema, Increased appetite, Abnormal thinking. DRUG INTERACTION Concurrent use with oxycodone, lorazepam and ethanol may increase the CNS effects. MECHANISM OF ACTION Pregabalin is an analog of the neurotransmitter GABA. It binds potently to the alpha2-delta subunit resulting in modulation of Ca channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P.