CompositionMecobalamin (1000 mcg/2 mL),Niacinamide (100 mg/2 mL),Pyridoxine Hydrochloride (100 mg/2 mL),Thiamine Hydrochloride(100 mg/2 mL) SALT INFORMATIONMecobalamin (1000 mcg/2 mL) TYPICAL USAGE Peripheral neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis. SIDE EFFECTS Anorexia, nausea, vomiting and diarrhoea, rash, headache, hot sensation, diaphoresis and pain or induration at IM injection site. DRUG INTERACTION Methylcobalamin is known to interact with other drugs like neomycin, aminosalicylic acid, H2-blockers and colchicine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Methylcobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes. Niacinamide (100 mg/2 mL) TYPICAL USAGE Hartnup disease, inflammatory skin disease, vitamin deficiency. SIDE EFFECTS Hepatotoxicity, cholestasis, portal fibrosis, headache, fatigue, nausea, heart burn, sore throat, dry hair, tautness of the face, inability of eye focusing. DRUG INTERACTION Niacinamide is known to interact with other drugs like carbamazepine, primidone. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Nutritional supplement: Niacinamide, is a component of two coenzymes, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are necessary for tissue respiration, glycogenolysis and lipid, amino acid, protein, and purine metabolism. Antihyperlipidemic: Niacinamide lowers serum cholesterol and triglyceride concentrations by inhibiting the synthesis of very low density lipoproteins (VLDL), which are precursors to the formation of low-density lipoproteins, the principal carrier of blood cholesterol. Pyridoxine Hydrochloride (100 mg/2 mL) TYPICAL USAGE Pharmaceutical Aid SIDE EFFECTS Nausea, stomach upset, skin rash, acute toxicity. DRUG INTERACTION Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval. MECHANISM OF ACTION Pharmaceutical Aid Thiamine Hydrochloride(100 mg/2 mL) TYPICAL USAGE Lung cancer and pancreatic cancer, mild chronic deficiency, severe deficiency, thiamine deficiency prophylaxis, thiamine deficiency treatment. SIDE EFFECTS Nausea, urticaria, Gi bleeding, angioneurotic edema, restlessness, pruritis, pulmonary edema, hemorrhage, cyanosis, DRUG INTERACTION Thiamine is known to interact with other drugs like aluminium hydroxide and oxide, amiloride (HCl), bumetanide, chlorthalidone, estradiol (Valerate), estrogens conjugated, fluorouracil, magnesium carbonate, magnesium oxides and hydroxides, metformin (HCl), phenobarbital Sodium, phenobarbitone, triamterene, vecuronium (Br). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. There are five known natural thiamine phosphate derivatives: thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and the recently discovered adenosine thiamine triphosphate (AThTP), and adenosine thiamine diphosphate. Each derivative has unique functions, however, most are involved as coenzymes.