CompositionSildenafil (50 mg)
SALT INFORMATIONSildenafil (50 mg) TYPICAL USAGE For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH). SIDE EFFECTS Headache, flushing, respiratory tract infection, angina pectoris, AV block, migraine, syncope. DRUG INTERACTION Inhibitors of CYP3A4 such as cimetidine and erythromycin are likely to reduce sildenafil clearance. MECHANISM OF ACTION Sildenafil inhibits phosphodiesterase type-5 (PDE5) which is responsible for cGMP degradation in the corpus cavernosum. Inhibition of PDE5 increases cGMP levels in the corpus cavernosum which results in smooth muscle relaxation and inflow of blood to the corpus cavernosum.