CompositionKetoconazole (2%w/v),Zinc Pyrithione (1%w/v) SALT INFORMATIONKetoconazole (2%w/v) TYPICAL USAGE Blastomycosis, Candidiasis, Candiduria, Chromomycosis, Chronic mucocutaneous candidiasis, Coccidloidomycosis, Histoplasmosis, Oesophageal candidiasis, orophyaryngeal candidiasis, Paracoccidloidomycosis. Chronic Vag candidiasis. SIDE EFFECTS Impotence, papilloedema, androgen suppression, oligospermia, gynecomastia, dizziness, headache, nausea, vomiting, alopecia, diarrhea, abdominal pain, urticaria, pruritus, itching, thrombocytopenia, photophobia. DRUG INTERACTION Ketoconazole is known to interact with other drugs like abiraterone acetate, alcohol, alfentanil (HCl), aliskiren, alprazolam, aluminium hydroxide and oxide, amphotericin B, aprepitant, artesunate, astemizole, beclomethasone (Dipropionate), bosentan, carbamazepine, cimetidine (HCl), cisapride, corticotropin, cyclosporin A, dabigatran, desonide, didanosine, docetaxel, eplerenone, erlotinib, famotidine, fexofenadine, flunisolide, indinavir (Sulphate). Always consult your physician for the change of dose regimen or an alternative drug choice that may strictly be required. MECHANISM OF ACTION Ketoconazole interacts with 14-? demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol causes inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone. Zinc Pyrithione (1%w/v) TYPICAL USAGE Dandruff, psoriasis, seborrheic dermatitis. SIDE EFFECTS Rashes, photosensitivity, skin irritation. DRUG INTERACTION Zinc pyrithione is known to interact with other drugs like sodium calciumedetate. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Its antifungal effect is proposed to derive from its ability to disrupt membrane transport by blocking the proton pump that energizes the transport mechanism.