CompositionPhenylephrine (0.8% w/v),Tropicamide (5% w/v)
SALT INFORMATIONPhenylephrine (0.8% w/v) TYPICAL USAGE Pressure agent used in hypotensive conditions. Nasal decongestant. Eye - mydriasis and to reduce intraocular tension. SIDE EFFECTS Anxiety, reflex bradycardia, tachycardia, arrhythmias, headache, cold extremities/gangrene, hypertension, nausea, vomiting, sweating, weakness, fear, restlessness, insomnia, confusion. DRUG INTERACTION May increase hypertensive effect of beta-blockers (nonselective), MAOI potentiate hypertension, methyldopa and TCA can increase the pressor response. MECHANISM OF ACTION Phenylephrine is a sympathomimetic with mainly direct effects on alpha-adrenergic receptors and weak beta-adrenergic activity. It causes vasoconstriction of the arterioles of the nasal mucosa and conjunctiva; activates the dilator muscle of the pupil to cause contraction; produces vasoconstriction of arterioles in the body and produces systemic arterial vasoconstriction. Tropicamide (5% w/v) TYPICAL USAGE Duodenal ulcer associated with h. Pylori, iridocyclitis, iritis, keratosis. SIDE EFFECTS Increased IOP (intraocular pressure), headache, drowsiness, blurred vision, dermatitis, eczematous rash, xerostomia. DRUG INTERACTION Tropicamide is known to interact with other drugs like amantadine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Tropicamide binds to and blocks the receptors in the muscles of the eye (muscarinic receptor M4). Tropicamide acts by blocking the responses of the iris sphincter muscle to the iris and ciliary muscles to cholinergic stimulation, producing dilation of the pupil and paralysis of the ciliary muscle.