CompositionChamomile (15mg),Clove Oil (0.01),Ethanol (31%)
SALT INFORMATIONChamomile (15mg) TYPICAL USAGE Cold, sinusitis, pharyngolaryngitis, bronchitis, inflammations of oral & pharyngeal cavities, aphthae, gingivitis, bleeding from the gums, inflammations of the oral mucosa. SIDE EFFECTS Anaphylactic shock, contact dermatitis, other severe allergic reactions. DRUG INTERACTION Chamomile is known to interact with other drugs like estrogens, benzodiazepines, pentobarbital, secobarbital, fentanyl, morphine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION 1. Inflammation results in induced expression and enzyme activity of cyclooxygenase-2 (COX-2), which produces inflammatory mediators such as prostaglandin E2. Increased expression of COX-2 has been implicated in the pathogenesis of various inflammatory disorders. Chamomile inhibits PGE2 production is due to the suppression of the COX-2 gene expression and direct inhibition of COX-2 enzyme activity. 2. Chamomile extracts cause minimal growth inhibitory effects on normal cells, but showed significant reductions in cell viability of cancer. Chamomile exposure induced apoptosis in cancer cells but not in normal cells at similar doses. 3. Anti-ulcerogenic effect associated with a reduced acid output, an increased mucin secretion, an increase in prostaglandin E (2) release and a decrease in leukotrienes. Clove Oil (0.01) TYPICAL USAGE Colic, flatulence, toothache. SIDE EFFECTS Seizures, acidosis, blood clotting disorder, coma, liver damage, hypersensitivity. DRUG INTERACTION Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval. MECHANISM OF ACTION Anesthetic: Eugenol has been used extensively in dentistry for its anesthetic and antianaerobic bacteria activity. Antimicrobial: In vitro studies demonstrate activity of clove oil against gram-positive and gram-negative bacteria pathogenic to humans, including multiresistant strains. Cancer: Sesquiterpenes from cloves reveal anticarcinogenic potential. Similarly, eugenol present in clove oil may ameliorate effects of environmental food mutagens. Anal fissure: The use of 1% clove oil cream resulted in significantly greater healing rates. Ethanol (31%) TYPICAL USAGE Antidote for methanol or ethylene glycol ingestion. SIDE EFFECTS Emotional lability, visual impairment, slurred speech, ataxia (low to moderate concentrations), hangover effects eg, nausea, headache, dizziness, tremor, lethargy, amnesia, hypothermia, hypoglycaemia (particularly in children), stupor, coma, resp depression, cardiomyopathy, hypertension, CV collapse damage to brain and liver which may lead to Wernike-Korsakoff syndrome (chronic excessive alcohol consumption). DRUG INTERACTION Ethanol is known to interact with other drugs like abacavir, gabapentin enacarbil, mipomersen, tizanidine, triprolidine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Ethanol affects the brainÂs neurons in several ways. It alters their membranes as well as their ion channels, enzymes, and receptors. Alcohol also binds directly to the receptors for acetylcholine, serotonin, GABA, and the NMDA receptors for glutamate. The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). It also inhibits NMDA receptor functioning. In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes.