CompositionAcyclovir (3% w/w)
SALT INFORMATIONAcyclovir (3% w/w) TYPICAL USAGE Genital herpes Simplex,Mucocutaneous H Simplex, H simplex encephalitis, H Simplex keratitis, Herpes zoster, Chicken , keratitis Infections of skin caused by Herpes simplex virus. This includes initial and recurrent genital herpes and herpes labialis, SIDE EFFECTS Nausea, stomach upset, skin rash, acute toxicity. DRUG INTERACTION Acyclovir may decrease levels of phenytoin(Dilantin) or valproic acid (Depakote, Depakote ER). Probenecid (Benemid) may increase acyclovir serum levels by decreasing renal excretion of acyclovir. Acyclovir may increase serum levels of theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin). MECHANISM OF ACTION Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.