CompositionAdapalene (0.10%),Clindamycin (1%)
SALT INFORMATIONAdapalene (0.10%) TYPICAL USAGE Acne vulgaris. SIDE EFFECTS Mild skin irritation, scaling, erythema, cutaneous dryness, sensations of stinging and burning, pruritus. DRUG INTERACTION Excessive skin irritation may occur if adapalene is used with other acne medications. Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents. MECHANISM OF ACTION Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Clindamycin (1%) TYPICAL USAGE Acne vulgaris, babesiosis, bacterial infections, bacterial vaginosis, dental infections, endocarditis, hidradenitis suppurativa, intra-abdominal infections, malaria, osteomyelitis, pelvic infections, peritonitis, pulmonary infection, septic arthritis, septicaemia. SIDE EFFECTS Elevated SGPT & SGOT, elevated alkaline phosphatase concentration, esophageal ulceration, pseudomembranous colitis, cardiac arrest, colonic ulceration, nausea, vomiting, abdominal pain, rashes, vaginitis, contact dermatitis. DRUG INTERACTION Clindamycin is known to interact with other drugs like bamifylline, calcium gluconate, distigmine (Br), gentamicin, lincomycin (HCl), pancuronium (Br), physostigmine, rivastigmine, rocuronium (Br), sodium thiosulphate. MECHANISM OF ACTION Systemic/vaginal clindamycin inhibits protein synthesis of bacteria by binding to the 50S ribosomal subunits of the bacteria. Specifically, it binds primarily to the 23s RNA subunit. Topical clindamycin reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes) , an anaerobe found in sebaceous glands and follicles.