CompositionEnalapril (5 mg),Losartan Potassium (25 mg)
SALT INFORMATIONEnalapril (5 mg) TYPICAL USAGE All grades of essential hypertension and renovascular hypertension. Adjunct in congestive heart failure. SIDE EFFECTS Initial hypotension may be severe and prolonged. Dizziness, headache, fatigue, persistent dry cough, abnormal taste, lassitude, rash, neutropenia, renal impairment or failure. DRUG INTERACTION Patients receiving diuretics may experience excessive reduction in blood pressure when enalapril is started. Close supervision for at least 2 hours after the start of enalapril and until blood pressure is stable is recommended if the diuretic cannot be stopped. Enalapril may increase potassium levels (hyperkalemia) in blood. Therefore, there is an increased risk of hyperkalemia when enalapril is given with potassium supplements or drugs that increase potassium levels (for example, spironolactone [Aldactone]). There have been reports of increased lithium (Eskalith, Lithobid) levels when lithium is used in combination with ACE inhibitors. The reason for this interaction is not known, but the increased levels may lead to toxicity from lithium. There have been reports that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin(Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors. MECHANISM OF ACTION Enalapril is de-esterified into the active enalaprilat resulting in potent inhibition of ACE thus leading to reduced levels of angiotensin II and aldosterone. Clinically, BP is reduced, salt and water retention is corrected. Ventricular hypertrophy is reversed. Renal blood flow is increased but in patients with renal impairment there may be oliguria or acute renal failure. Losartan Potassium (25 mg) TYPICAL USAGE Mild to moderate hypertension. Diabetic nephropathy in type 2 diabetes mellitus. SIDE EFFECTS Headache, dizziness, back pain, myalgia, respiratory tract disorders, fatigue, GI disturbances, transient elevation of liver enzymes, impaired renal function, taste disturbances and hyperkalaemia. DRUG INTERACTION Losartan potassium is known to interact with other drugs like aldesleukin, alprostadil, diazoxide, fluconazole, indomethacin, lithium. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Losartan potassium is an angiotensin II receptor antagonist. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively antagonising its binding to AT1 receptors.