CompositionAtorvastatin(NA),Cholecalciferol (NA) SALT INFORMATIONAtorvastatin(NA) TYPICAL USAGE Familial hypercholesterolaemia, homozygous familial hypercholesterolemia, hypercholesterolaemia, hyperlipoproteinaemia, hypertriglyceridaemia. SIDE EFFECTS Flatulence, weakness, headache, diarrhea, fever, myalgia, constipation, insomnia, abdominal pain, skin rashes, blurred vision, pharyngitis, dyspepsia, malaise, asthenia, arthralgia, elevation of liver enzymes, myopathy, backache, increased intracranial pressure, GI disturbance, sinusitis. DRUG INTERACTION Atorvastatin is known to interact with other drugs like aliskiren, amprenavir, cimetidine (HCl), colestipol (HCl), cyclosporin A, digoxin, erythromycin, mibefradil (Di HCl), nicotinic acid, repaglinide, warfarin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Atorvastatin selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway, this results in a subsequent decrease in hepatic cholesterol levels. Cholecalciferol (NA) TYPICAL USAGE Managing hypocalcemia in patients undergoing dialysia for chronic renal failure. Renal osteodystrophy. Hypocalaemia and Hyperphosphataemia. Vitamin D dependent rickets, renal tubular osteomalacia. SIDE EFFECTS Nausea, stomach upset, skin rash, acute toxicity. DRUG INTERACTION Increased risk of hypercalcaemia if given with thiazide diuretics, calcium or phosphate. MECHANISM OF ACTION Vit D may have anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant & mood-modulatory activities. Along with parathyroid hormone & calcitonin, regulate serum calcium conc.