Composition: “Atorvastatin Calcium 40mg”
Atorvastatin is in a group of drugs called “statins”. It is used primarily for lowering blood cholesterol and for preventing risks associated with cardiovascular disease.
Mechanism of action:
- It acts by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.
- Primary uses of atorvastatin are dyslipidemia and cardiovascular disease. Help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood.
- Secondary uses are prevention of myocardial infarction, stroke, unstable angina.
- Liver diseases like Cholestasis, Hepatic encephalopathy, Hepatitis and jaundice.
- Pregnancy and Breastfeeding
- Acute renal failure
- Myopathy with elevation of creatinine kinase (CK) and rhabdomyolysis are the major adverse effect.
Diarrhea, Dyspepsia, Nausea, Arthralgia, Myalgia are the common adverse effect.
- Interactions with clofibrate, fenofibrate, gemfibrozil, used usually in combination with statins, increase the risk of myopathy and rhabdomyolysis.
- Co-administration of atorvastatin with one of CYP3A4 inhibitors may increase serum concentrations of atorvastatin, which may lead to adverse reactions.
- Niacin and colchicine is proved to increase the risk of myopathy or rhabdomyolysis
- Vitamin D supplement lowers atorvastatin and active metabolite concentration.
- Co-administration of grapefruit juice with atorvastatin may cause an increase in Cmax and AUC may lead to overdose toxicity.