Composition: Atorvastatin Calcium 40mg + Asprin 150mg
- Atorvastatin is in a group of drugs called “statins”. It is used primarily for lowering blood cholesterol and for preventing risks associated with cardiovascular disease.
Mechanism of action:
- It acts by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.
- Primary uses of atorvastatin are dyslipidemia and cardiovascular disease. Help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood.
- Secondary uses are prevention of myocardial infarction, stroke, unstable angina.
- Liver diseases like Cholestasis, Hepatic encephalopathy, Hepatitis and jaundice.
- Pregnancy and Breastfeeding
- Acute renal failure
- Myopathy with elevation of creatinine kinase (CK) and rhabdomyolysis are the major adverse effect.
Diarrhea, Dyspepsia, Nausea, Arthralgia, Myalgia are the common adverse effect.
- Interactions with clofibrate, fenofibrate, gemfibrozil, used usually in combination with statins, increase the risk of myopathy and rhabdomyolysis.
- Co-administration of atorvastatin with one of CYP3A4 inhibitors may increase serum concentrations of atorvastatin, which may lead to adverse reactions.
- Niacin and colchicine is proved to increase the risk of myopathy or rhabdomyolysis
- Vitamin D supplement lowers atorvastatin and active metabolite concentration.
- Co-administration of grapefruit juice with atorvastatin may cause an increase in Cmax and AUC may lead to overdose toxicity.
- Aspirin, also known as acetylsalicylic acid [ASA], often used as an analgesic to relieve minor pains and to reduce fever (antipyretic), and as an anti-inflammatory medication. It is also has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds platelet molecules together to create a patch over damaged walls of blood vessels and block blood vessels.
- It is used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in people at high risk of developing blood clots.
Mechanism of action:
The effect of asprin is dose dependent as below:
- Low doses (75 to 150 mg/day) are sufficient to irreversibly acetylate serine 530 of cyclooxygenase (COX)-1 leads to inhibition of platelet generation of thromboxane A2, resulting in an antithrombotic effect.
- Intermediate doses (650 mg to 4 g/day) inhibit COX-1 and COX-2, blocking prostaglandin (PG) production, and have analgesic and antipyretic effects.
- Gastrointestinal ulcers, stomach bleeding, and ringing in the ears, especially with higher doses.
- In children and adolescents, aspirin is not recommended for flu-like symptoms or viral illnesses, because of the risk of Reye's syndrome.
- Asprin may interact with alcohol, corticosteroids, analgin.
- Asprin on concurrent administration with Phenylbutazone and oxyphenbutazonen may increase risk of GI ulceration.
- It may potentiate the effects of of anticoagulants, methotrexate and oral hypoglycemic drugs.