SALT INFORMATIONItraconazole (100mg) TYPICAL USAGE Feeling of gastric fullness, epigastric pain, anorexia, heartburn, regurgitation, bloating nausea and vomiting. SIDE EFFECTS Hepatitis, hypertension, dizziness, headache, fatigue, nausea, vomiting, diarrhea, abdominal pain, pruritus, hallucination, somnolence, hair loss, edema. DRUG INTERACTION Itraconazole is known to interact with other drugs like aliskiren, alprazolam, artesunate, astemizole, bosentan, buspirone (HCl), busulphan, calcium carbonate, carbamazepine, cisapride, cyclosporin A, digoxin, erlotinib, felodipine, fexofenadine, indinavir (Sulphate), lovastatin, midazolam, mizolastine. MECHANISM OF ACTION Itraconazole interacts with 14-? demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.