CompositionNifedipine (10 mg)
SALT INFORMATIONNifedipine (10 mg) TYPICAL USAGE Adjunct in GI-disorders, Myocardial infarction, Stroke. SIDE EFFECTS Allergy, Hypokalemia, Hyperglycemia, Blurred vision, Hypoglycemia. DRUG INTERACTION Potentiates antihypertensives. Increases the effects of neuromuscular-blocking agents and CYP1A2 substrates (e.g. theophylline, aminophylline). MECHANISM OF ACTION Nifedipine blocks the slow calcium channels thus preventing the flow of calcium ions into the cell. It produces peripheral and coronary vasodilatation, reduces afterload, peripheral resistance and BP, increases coronary blood flow and causes reflex tachycardia. It has little or no effect on cardiac conduction and rarely has negative inotropic activity.