CompositionHydrochlorothiazide (12.5mg),Telmisartan (40mg) SALT INFORMATIONHydrochlorothiazide (12.5mg) TYPICAL USAGE Disorders of calcium balance, Edema, Heart failure, Hypertension, Oedema, and can also be given in adjunctive therapy as an alternative drug of choice in Diabetes insipidus. SIDE EFFECTS Dizziness, Thirst, Headache, Nausea, Gout, Impotence, Polyuria, Night cramps. DRUG INTERACTION None mentioned. MECHANISM OF ACTION Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Telmisartan (40mg) TYPICAL USAGE It is used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure SIDE EFFECTS Dizziness, back pain, sinusitis, pharyngitis and diarrhoea. DRUG INTERACTION Telmisartan is known to interact with other drugs like acetylsalicylic acid, amifostine, amiloride, diclofenac, digoxin, fenoprofen, flurbiprofen, ketoprofen, ketorolac, lumiracoxib, meloxicam, nabumetone, spironolactone, tiaprofenic acid, tolmetin, trandolapril. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Telmisartan interferes with the binding of angiotensin II to the angiotensin II AT1-receptor by binding reversibly and selectively to the receptors in vascular smooth muscle and the adrenal gland. As angiotensin II is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone and improve carbohydrate and lipid metabolism.