CompositionAloe vera (10 % w/w),Vitamin E () SALT INFORMATIONAloe vera (10 % w/w) TYPICAL USAGE Treating minor wounds, burns, eczema, and psoriasis. Moisturizing the skin. SIDE EFFECTS Topical aloe vera might cause skin irritation. Oral aloe, which has a laxative effect, can cause cramping and diarrhea. This may cause electrolyte imbalances in the blood of people who ingest aloe for more than a few days. Aloe vera can also stain the colon, thus making it difficult to visualize the colon during a colonoscopy. DRUG INTERACTION Aloe vera is known to interact with other drugs like digoxin, glimepiride, glyburide, insulin, pioglitazone, rosiglitazone, chlorpropamide, glipizide. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Healing properties: Glucomannan, a mannose-rich polysaccharide, and gibberellin, a growth hormone, interacts with growth factor receptors on the fibroblast, thereby stimulating its activity and proliferation, which in turn significantly increases collagen synthesis after topical and oral Aloe vera. Aloe gel not only increased collagen content of the wound but also changed collagen composition (more type III) and increased the degree of collagen cross linking. Due to this, it accelerated wound contraction and increased the breaking strength of resulting scar tissue. Effects on skin exposure to UV and gamma radiation: The administration of aloe vera gel, an antioxidant protein, metallothionein, is generated in the skin, which scavenges hydroxyl radicals and prevents suppression of superoxide dismutase and glutathione peroxidase in the skin. It reduces the production and release of skin keratinocyte-derived immunosuppressive cytokines such as interleukin-10 (IL-10) and hence prevents UV-induced suppression of delayed type hypersensitivity. Anti-inflammatory action: Aloe vera inhibits the cyclooxygenase pathway and reduces prostaglandin E2 production from arachidonic acid. Effects on the immune system: Alprogen inhibit calcium influx into mast cells, thereby inhibiting the antigen-antibody-mediated release of histamine and leukotriene from mast cells. Antiviral and antitumor activity: These actions may be due to indirect or direct effects. Indirect effect is due to stimulation of the immune system and direct effect is due to anthraquinones. The anthraquinone aloin inactivates various enveloped viruses such as herpes simplex, varicella zoster and influenza. Moisturizing and anti-aging effect: Mucopolysaccharides help in binding moisture into the skin. Aloe stimulates fibroblast which produces the collagen and elastin fibers making the skin more elastic and less wrinkled. It also has cohesive effects on the superficial flaking epidermal cells by sticking them together, which softens the skin. The amino acids also soften hardened skin cells and zinc acts as an astringent to tighten pores. It also has anti-acne effect. Antiseptic effect: Aloe vera contains 6 antiseptic agents: Lupeol, salicylic acid, urea nitrogen, cinnamonic acid, phenols and sulfur. They all have inhibitory action on fungi, bacteria and viruses. Vitamin E () TYPICAL USAGE Used in cosmetic products for the skin and the hair. SIDE EFFECTS High doses of Vitamin E acetate can also cause nausea, diarrhea, stomach cramps, fatigue, weakness, headache, blurred vision, rash, and bruising and bleeding. DRUG INTERACTION Vitamin E acetate is known to interact with other drugs like Amprenavir, Orlistat. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Vitamin E protects the cells against free radicals and prevents the peroxidation of body fats. It is also an effective moisturizing agent and improves the elasticity and smoothness of the skin.