SALT INFORMATIONDiclofenac (0.0116) TYPICAL USAGE Adnexitis, dysmenorrhoea, inflammation, migraine, post-operative pain, post-traumatic pain, rheumatoid arthritis. SIDE EFFECTS Dizziness, vertigo, headache, rashes, GI upset, elevation of liver enzymes, GI hemorrhage, vision disturbances, erythema multiforme. DRUG INTERACTION Diclofenac is known to interact with other drugs like cholestyramine, colestipol (HCl), cyclosporin A, misoprostol, nitrendipine, sucralfate. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Diclofenac inhibits both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.