CompositionFluticasone Propionate (0.005% w/w)
SALT INFORMATIONFluticasone Propionate (0.005% w/w) TYPICAL USAGE Allergic rhinitis, asthma, atopic eczema, contact sensitivity reactions, dermatitis, discoid eczema, discoid lupus erythematosus, eczema, infantile eczema, neurodermatoses, perennial rhinitis, psoriasis, purigo nodularis, seborrheic dermatitis. SIDE EFFECTS Glaucoma, cataract, growth retardation, adrenocortical suppression, decrease in bone mineral density, pruritus, dysphonia, allergic contact dermatitis, cough, oral candidiasis, local burning, hyperpigmentation, hypertrichosis, vocal cord myopathy, throat irritation, superficial blood vessels dilatation, superficial blood vessels thinning. DRUG INTERACTION Fluticasone propionate is known to interact with other drugs like carbamazepine, cyclosporin A, frusemide or furosemide, phenytoin (Na), primidone, rifampicin, theophylline, warfarin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Fluticasone propionate binds to the glucocorticoid receptor with high affinity and produces alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue.