CompositionMecobalamin (750 mcg),Pyridoxine (1.5 mg),Nicotinamide (45 mg)
SALT INFORMATIONMecobalamin (750 mcg) TYPICAL USAGE Peripheral neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis. SIDE EFFECTS Anorexia, nausea, vomiting and diarrhoea, rash, headache, hot sensation, diaphoresis and pain or induration at IM injection site. DRUG INTERACTION Methylcobalamin is known to interact with other drugs like neomycin, aminosalicylic acid, H2-blockers and colchicine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Methylcobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes. Pyridoxine (1.5 mg) TYPICAL USAGE Anaemia, Deficiency states, Idiopathic sideroblastic anaemia, Isoniazid neuropathy, Oedema and ascites in cirrhosis of the liver, Premenstrual syndrome, Schizophrenia and other psychoses, Vitamin deficiency. SIDE EFFECTS Dizziness, Drowsiness, Blurred vision, Pain, Burning. DRUG INTERACTION None mentioned. MECHANISM OF ACTION Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA). Nicotinamide (45 mg) TYPICAL USAGE Hartnup disease, inflammatory skin disease, vitamin deficiency. SIDE EFFECTS Hepatotoxicity, cholestasis, portal fibrosis, headache, fatigue, nausea, heart burn, sore throat, dry hair, tautness of the face, inability of eye focusing. DRUG INTERACTION Nicotinamide is known to interact with other drugs like carbamazepine, primidone. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Nutritional supplement: Nicotinamide, is a component of two coenzymes, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are necessary for tissue respiration, glycogenolysis and lipid, amino acid, protein, and purine metabolism. Antihyperlipidemic: Nicotinamide lowers serum cholesterol and triglyceride concentrations by inhibiting the synthesis of very low density lipoproteins (VLDL), which are precursors to the formation of low-density lipoproteins, the principal carrier of blood cholesterol.