CompositionLidocaine (100 gm)
SALT INFORMATIONLidocaine (100 gm) SIDE EFFECTS Allergy, hypotension, bronchospasm, coma, seizures, hypertension, tissue necrosis, angina, sinus bradycardia, respiratory depression, blurred vision, tremors, respiratory depression, bradycardia, convulsions, hypersensitivity, cardiac arrest, CNS toxicity, dizziness, headache, drowsiness, nausea, vomiting, anxiety, restlessness, palpitation, nervousness, tinnitus, abdominal pain, confusion. DRUG INTERACTION Lignocaine is known to interact with other drugs like alcuronium (Cl), amphotericin B, amprenavir, atracurium (Besylate), cimetidine (HCl), edrophonium (Cl), enflurane, fosphenytoin, halothane, nadolol, oxprenolol (HCl), pentazocine, propafenone (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain but by aborting their birth in the first place.