CompositionDiclofenac Sodium (1 % w/w),Linseed Oil (3 % w/w),Methyl Salicylate (10 % w/w,)
SALT INFORMATIONDiclofenac Sodium (1 % w/w) TYPICAL USAGE Bacterial eye infections and inflammation SIDE EFFECTS Nausea, stomach upset, skin rash, acute toxicity. DRUG INTERACTION Diclofenac, like other NSAIDs is associated with several suspected or probable interactions that affect the action of other drugs. Some examples are discussed below. Diclofenac may increase the blood levels of lithium (Eskalith) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity. Diclofenac may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation of blood pressure. When diclofenac is used in combination with aminoglycoside antibiotics [for example, gentamicin (Garamycin)] the blood levels of the aminoglycoside may increase, presumably because the elimination of aminoglycosides from the body is reduced. This may lead to more aminoglycoside-related side effects. Individuals taking oral blood thinners or anticoagulants [for example,warfarin (Coumadin)] should avoid diclofenac because diclofenac also thins the blood, and excessive blood thinning may lead to bleeding. Combining NSAIDs with methotrexate (Rheumatrex, Trexall) may reduce the elimination of methotrexate from the body and result in increased side effects from methotrexate. MECHANISM OF ACTION This medication is an NSAID, prescribed for severe pain. This medication decreases the hormones that cause inflammation and pain in the body. Linseed Oil (3 % w/w) TYPICAL USAGE Used to reduce cholesterol levels, to slow prostate cancer growth before surgery, and topically for skin irritation. SIDE EFFECTS Difficulty breathing, closing of your throat, swelling of your lips, tongue, or face. DRUG INTERACTION None mentioned. MECHANISM OF ACTION Not known. Methyl Salicylate (10 % w/w,) TYPICAL USAGE Musculoskeletal disorders, peripheral vascular disease, respiratory tract infections, soft tissue disorders. SIDE EFFECTS Irritative skin reactions, skin ulcers, stinging of skin. DRUG INTERACTION Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval. MECHANISM OF ACTION Methyl salicylate is considered a non-selective COX inhibitorÂthat is, it inhibits two isoforms of cyclooxygenase, COX-1 and COX-2. The analgesic, antipyretic, and anti-inflammatory activity of NSAIDs appears to be achieved mainly through inhibition of COX-2, whereas inhibition of COX-1 would be responsible for unwanted effects on platelet aggregation and the gastrointestinal tract. Methyl salicylate directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms.