CompositionClozapine (50 mg)
SALT INFORMATIONClozapine (50 mg) TYPICAL USAGE Bipolar disorders, pituitary diabetes insipidus, schizophrenia and other psychoses, tremor. SIDE EFFECTS Bronchospasm, orthostatic hypotension, eosinophilia, seizures, neuroleptic malignant syndrome, toxic delirium, dizziness, vertigo, headache, drowsiness, fatigue, constipation, dry mouth, blurred vision, sedation, syncope, influenza like syndrome. DRUG INTERACTION Clozapine is known to interact with other drugs like alcohol, alprazolam, apomorphine, bleomycin, cabergoline, carbamazepine, chloramphenicol, cimetidine (HCl), ciprofloxacin, cyclophosphamide, diazepam, erythromycin, fluoxetine (HCl), fluspirilene, fluvoxamine (Maleate), guanethidine, haloperidol, lithium, loprazolam, metoclopramide (HCl), noradrenaline (Acid Tartrate), paroxetine, penicillamine, sulfapyridine, sulphamethoxazole, trimethoprim, warfarin (Na). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Clozapine has relatively weak dopamine receptor-blocking activity at D1, D2, D3 and D5 receptors but has high affinity for the D4 receptor. It has also blocking effects on serotonin, ?-adrenergic histamine H1 and cholinergic receptors.