SALT INFORMATIONTimolol (5ml) TYPICAL USAGE Angina, glucoma, hypertension, iron deficiency anaemia, migraine, migraine prophylaxis, myocardial infarction. SIDE EFFECTS Bradycardia, bronchospasm, fatigue, cold extremities, insomnia, bradycardia, depression, nausea and vomiting, headedness, paresthesias. DRUG INTERACTION Timolol is known to interact with other drugs like adrenaline, albuterol, apraclonidine (HCl), clonidine (HCl), indomethacin, ipodate, lignocaine, metrizamide, paregoric, propylthiouracil. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Timolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta(2)-blockade results in an increase in peripheral vascular resistance.