CompositionHydrochlorothiazide (12.5 mg)
SALT INFORMATIONHydrochlorothiazide (12.5 mg) TYPICAL USAGE Disorders of calcium balance, Edema, Heart failure, Hypertension, Oedema, and can also be given in adjunctive therapy as an alternative drug of choice in Diabetes insipidus. SIDE EFFECTS Dizziness, Thirst, Headache, Nausea, Gout, Impotence, Polyuria, Night cramps. DRUG INTERACTION None mentioned. MECHANISM OF ACTION Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption.