CompositionMelatonin (3 mg),Zolpidem Tartrate ()
SALT INFORMATIONMelatonin (3 mg) TYPICAL USAGE Disturbed biorhythms, sleep disorders. SIDE EFFECTS Increased seizure activity, drowsiness, headache, disruption of normal circadian rhythm. DRUG INTERACTION Melatonin is known to interact with other drugs like nifedipine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate. By binding to melatonin receptors 1 and 2, the downstream signallling cascades have various effects in the body. The plasma levels of melatonin are high at night and low during the day and it appears to have a role in circardian rhythm regulation. This action of melotonin finds a possible place in the management of jet lag and other sleep disorders. Melatonin is also being used in the treatment of cluster headaches. Zolpidem Tartrate () TYPICAL USAGE Insomnia, nausea, vertigo, labyrinthine disorders. SIDE EFFECTS Dizziness, headache, drowsiness, confusion, GI upset, depression, tremor. DRUG INTERACTION Zolpidem tartrate is known to interact with other drugs like alcohol, carbamazepine, isoniazid, nelfinavir, nevirapine, phenobarbitone, phenytoin (Na), rifampicin, ritonavir. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. MECHANISM OF ACTION Zolpidem tartrate acts by binding to the benzodiazepine (BZD) receptors of the GABA receptor complex resulting in neuronal hyperpolarisation, action potential inhibition, increased in chloride conductance and decreased in neuronal excitability.