CompositionSimvastatin (10 mg)
SALT INFORMATIONSimvastatin (10 mg) TYPICAL USAGE Hyperlipidaemia,Cardiovascular risk reduction,Homozygous familial hypercholesterolaemia. SIDE EFFECTS Headache, nausea, flatulence, heartburn, abdominal pain, diarrhoea/constipation. DRUG INTERACTION May cause slight elevation of serum digoxin. May increase risk of bleeding when used with coumarins and fluindione. MECHANISM OF ACTION Simvastatin is a prodrug metabolised in the liver to form the active ?-hydroxyacid derivative. This inhibits the conversion of HMG-CoA to mevalonic acid by blocking HMG-CoA reductase, an early and rate-limiting step in cholesterol biosynthesis. It reduces total cholesterol, LDL-cholesterol and triglycerides and increases HDL-cholesterol levels.